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Instead of paying fees per transaction, you can choose among three monthly subscription tiers and get the first $500,000 per year processed at no extra cost. Stax, formerly Fattmerchant, offers a streamlined, month-to-month merchant account service. Stripe’s affordable equipment and no monthly fees make this platform ideal for small businesses, whether you’re an e-commerce store, online educator or brick-and-mortar shop. Stripe customer support is available through live chat and phone 24/7. Payouts come at a scheduled interval or as soon as two business days after a transaction, depending on the settings you choose. Stripe is a convenient option if you run multiple online businesses or brands because you can operate them all from one merchant account with separate reporting. You’ll pay $59 for the basic contactless card reader or $249 for the handheld mini POS. You’ll also pay 0.4% as a chargeback protection fee. In-person, swiped or chipped transactions: 2.7% + $0.05 (+ 1% for international cards and currency conversion).
In January 2017, following the premiere of Deutscher's opera, Cinderella, in Vienna, an article entitled "Alma and the dangerous love of melody" appeared in the Viennese newspaper Der Standard, which expressed the hope that Deutscher's melodious music may help to change the prevailing attitudes in contemporary classical music and inject a new life into the world of opera, by steering it back towards melody. and sometimes it's a little bit difficult for people to take me seriously because I'm just a little girl." Commenting on the public perception of child prodigies and their musical output, Deutscher told the newspaper Die Zeit when she was 10: "I want my music to be taken seriously. Much of the critical response to Deutscher's compositions in the first years of her public exposure centered on her young age and status as a child prodigy. Her melodies themselves often arrive unbidden, including in her dreams. In September 2014, a viral YouTube mashup video released by Israeli musician Kutiman ("Give It Up") featured a 4-second ostinato assembled from pieces of one of Deutscher's early videos.īy 2020, Deutscher's official YouTube channel has gathered more than ten million views and 118,000 subscribers. He explained that the family had been unprepared for the intense exposure, and that they view as their most important tasks protecting her and ensuring that she has a happy childhood. Guy Deutscher spoke of his concerns surrounding Alma's initial press coverage. Television crews arrived at her family home the next day. A new Mozart?", with a link to one of Deutscher's videos. And after it finished I asked my parents 'How could music be so beautiful?'"ĭeutscher's initial media exposure may be traced to writer and comedian Stephen Fry publicising her YouTube channel when she was seven, by writing: "Simply mind-blowing: Alma Deutscher playing her own compositions. Within less than a year she was playing Handel sonatas." In a 2017 interview with the Financial Times, Deutscher said: "I remember when I was three and I was listening to a lullaby by Richard Strauss, I loved it! I especially loved the harmony I always call it the Strauss harmony now. She was so excited by it and tried playing on it for days on end, so we decided to try to find her a teacher. "For her third birthday I bought her a little violin as a toy. According to her father, she could name the notes on a piano when she was two. At seven, she composed her first short opera, at nine, a violin concerto, and her first full-length opera at age ten. These first written notations were unclear, but by six, she could write clear compositions and had composed her first piano sonata. At four she was composing and improvising on the piano, and by five, had begun writing down her compositions. She began playing piano at the age of two, followed by violin at three. Backgroundĭeutscher was born in Basingstoke in 2005, the daughter of literature professor Janie Deutscher (née Steen) and Israeli linguist Guy Deutscher. She gave her debut at Carnegie Hall in December 2019. At the age of twelve, Deutscher premiered her first piano concerto. premiere a year later at Opera San Jose was released on DVD by Sony Classical. At the age of ten she wrote her first full-length opera, Cinderella, which had its European premiere in Vienna in 2016 under the patronage of conductor Zubin Mehta. Aged nine, she wrote a concerto for violin and orchestra. At age seven, she completed a short opera The Sweeper of Dreams. Alma Elizabeth Deutscher is an English child prodigy, composer, pianist and violinist.Īt age five, she composed her first piano sonata. Apple Watch Series 4 (2018 model) or older Upgrade? Yes, you’ll get a much better experience (and your battery is likely in rough shape)Ĭompared with the rest of the models above, the Apple Watch Series 4 is the most likely to be showing its age at this point. If you’ve been happy with the SE’s performance, you’re probably best off sticking with the upgraded version. It’s a clear path from the Series 5 to the Series 8 or Apple Watch Ultra if you choose to upgrade. Their processors are about 20% slower than the Series 6, 7 and 8, so if you’ve noticed the screen responding more slowly to your taps, or apps taking forever to launch, consider upgrading, but don’t think it is totally essential. Apple Watch Series 5 or Apple Watch SE (1st generation) (2019 models) Upgrade? Maybe, if your Watch is feeling sluggish or smallĮven though they’re more than three years old, the Apple Watch Series 5 and the original Apple Watch SE are still great devices and there’s a good chance they’re still fulfilling your needs. But if you’ve been using the Watch for this long and haven’t yet minded the screen size, we recommend you keep it. If you’ve felt like your Series 6’s screen is too small, then consider the Series 8 (or the Ultra). The result is nearly 20% more screen real estate, which, in day-to-day use, makes a noticeable difference. Apple made the Series 7’s case bigger my 1 mm on both the small and large versions, and shrunk the bezels around the display. The biggest difference between the Apple Watch Series 7 and the Series 6 is the size of the screen. Apple Watch Series 6 (2020 model) Upgrade? Maybe, but only if you’re looking for a larger screen, Apple Watch Ultra features or ovulation tracking If you’re coming from a “Series” Watch, you should almost certainly skip it. But it’s only going to be an upgrade if you’ve been wearing the first-generation SE. It’s a perfectly fine device for someone who is just starting out with a smartwatch and doesn’t want to make a big investment, as well as kids and other family members who don’t have their own phone, thanks to the family setup feature. Some people will find it too large for their wrist, though.ĭon’t buy an Apple Watch SE. If the 49mm screen size, titanium body or multiday battery life appeal to you, moving up to an Apple Watch Ultra will definitely be an upgrade. It’s the biggest departure from the Apple Watch’s design in the product’s history, and from personal experience, it’s easy to fall in love with even if you’re not an extreme athlete taking advantage of its more rugged features such as more precise GPS, and 86-decibel emergency siren and improved underwater capabilities including greater waterproofing and a Depth app. The Apple Watch Ultra is a different story. We don’t think it makes a lot of sense to buy a whole new Watch for car crash detection, though, and especially not if you own an iPhone 14, which also supports this alert system. It’s only worth the upgrade if you think the retrospective ovulation estimate feature may be useful if you’re trying to get pregnant (but it isn’t an FDA-approved family planning method). The Apple Watch Series 8 is almost identical, both inside and out, to last year’s Series 7, including the same processor speeds. Apple Watch Series 7 (2021 model) Upgrade? Not unless you are particularly interested in the new fertility tracking feature or the Apple Watch Ultra Not only does the Apple Watch SE look like the more expensive Series 8, it also offers many of the same features. So if you are going to upgrade and you want to get the most value back, consider selling on eBay or another market-based venue. The maximum Apple offers through its trade-in program as of publication is $155, regardless of how much you paid for it. Unlike with iPhones, which can usually net a decent trade-in value if they’re in good condition, you’re not likely to get much back for turning in a used Apple Watch. If you’re looking for an in-depth analysis of the new phones, we suggest reading what The Wall Street Journal’s Nicole Nguyen has to say about the Series 8 and SE, as well as the Ultra. (See more about upgrading to those below. Our advice here is the same as when it comes to upgrading your iPhone : If you’re happy with your current device, don’t upgrade just because there’s something new.Īpple also launched two other Watches alongside the Series 8: the Apple Watch Ultra and the second-generation Apple Watch SE. Its body is identical to last year’s Series 7, and both models have the same processor-meaning the same level of responsiveness and speed for apps-as the Series 6. The 2022 Apple Watch Series 8 follows that trend. In the eight years since it was introduced, the Apple Watch has reached a point where each successive model adds a handful of features, but doesn’t necessarily justify an upgrade even if you got yours a few years ago. Although immune checkpoint inhibitors have changed the treatment landscape for a variety of cancer types, they have previously been shown to be less effective in breast cancer. By blocking PD-1, pembrolizumab triggers immune cells to locate and kill cancer cells. Pembrolizumab is an immune checkpoint inhibitor, which binds to a protein called PD-1 on the surface of immune cells. If we prevent recurrence, we cure more patients, but we need longer-term data for confirmation." "These are preliminary data, but they provide a strong sign that the addition of immune therapy to neoadjuvant chemotherapy prevents breast cancer recurrence. Speaking of the trial, Professor Schmid said: An improvement in event-free survival was also observed in patients who received the immunotherapy combination treatment. The patients treated with the pembrolizumab-chemotherapy combination exhibited a significant improvement in pathological complete response compared with that seen in patients who received the placebo (64.8 vs 51.2%, respectively). The analysis presented at the ESMO Congress 2019 was performed on 602 evaluable patients after a median follow-up of 15.5 months. In the trial, funded by Merck, patients were treated with either immunotherapy plus chemotherapy or placebo plus chemotherapy. administered prior to surgery to remove the tumour) could improve pathological complete response and event-free survival in women with early TNBC. KEYNOTE-522 investigated whether adding pembrolizumab, an immunotherapy, to chemotherapy in a neoadjuvant setting (i.e. This provides the best chance of pathological complete response (no trace of cancer in tissue samples following therapy and surgery). Patients with TNBC typically receive chemotherapy, followed by surgery to remove the tumour. Therefore, hormone therapy and drugs that work by targeting these receptors are ineffective against TNBC. This breast cancer subtype is characterised by the absence of receptors for the hormones oestrogen and progesterone, and receptors for the HER2 protein. TNBC accounts for approximately 15% of all breast cancer cases and is more likely to affect younger people. An aggressive and difficult-to-treat cancer The interim results of the KEYNOTE-522 trial were presented on 29 th September by Professor Schmid at the ESMO Congress 2019 in Barcelona, Spain. The trial, led by Professor Peter Schmid, Lead for the Centre for Experimental Cancer Medicine ( Barts Cancer Institute, Queen Mary University of London), is the first phase III immunotherapy trial in early breast cancer. Herein we will provide an overview of recent clinical studies of neoadjuvant immune checkpoint inhibitors in patients with triple-negative breast cancer, especially focusing on the recently presented and published KEYNOTE-522, IMpassion031 and GeparNUEVO trials.Ītezolizumab breast cancer immune checkpoint inhibitors immunotherapy pembrolizumab triple-negative breast cancer.Results of an interim analysis from the KEYNOTE-522 trial have shown a treatment combination of immunotherapy plus chemotherapy to improve response rates in patients with early triple-negative breast cancer (TNBC). However, several questions remain unanswered, including the identification of predictors of response to immunotherapy in this setting, and further efforts aimed at identifying reliable predictors and clarifying the effective role of PD-L1 status, tumor mutational burden, tumor-infiltrating lymphocytes and other biomarkers are warranted. Novel systemic treatment options have recently been assessed as part of the neoadjuvant approach, such as the addition of immune checkpoint inhibitors to cytotoxic chemotherapy. Stage I-III triple-negative breast cancer accounts for approximately 15-20% of new diagnoses of early breast cancer. But if you are looking for top quality work, high quality components, top level customer service at a fair price DR is the shop for you. All DR engine builds come with unlimited technical support at no charge.ĭuncan Racing is not a discount shop, if cheap is what you want DR is not the place. All DR engine builds come with complete technical instructions cover break in, tuning, lubrication, etc. Once engine build is complete DR will schedule pick up or ship engine to client. (For select models at additional cost DR offers test runs on the engine before engine is shipped back-contact DR for more details) DR performs all applicable bench tests to ensure engine is ready for service. When all components are prepared engine is reassembled by DR Master Technician. Performing necessary machine work, cleaning and prepping for reassembly. Once DR and Client have agreed on a course of action. The goal here is to educate our clients so they can make the best decisions for their situation. During the estimate phase DR will answer all questions and cover all options. DR will compile a comprehensive email outlining the issues with the engine and estimating the build costs. For clients unable to communicate in person or via telephone. Once DR is equipped with teardown notes and preliminary notes, DR will contact client and schedule a time to discuss their engine either in person or by phone. Once the dissemble process is complete, DR will compile a build estimate. Once disassembled certain components will undergo a preliminary wash for further examination. DR keeps extensive notes on disassembly process. ATV riders can call the SVIA at 1-80 and we’ll even pay for the training. All components are checked, bearings, gears, crankshaft, rod, piston, valves etc. Off-road riders can enroll in the DirtBike SchoolSM by calling 1-87. Motors can be shipped to DR from most countries and all states- Shipping Tip section for more information.įollowing is a quick summary of the process once motor arrives at DR facility it is transferred to the engine department, one logged in and paper work filled out the engine goes through a thorough examination. (Contact DR to confirm service is offered for your make/model)Īll engine builds at DR are given the same attention from stockers to championship contenders. DR also offers its engine build services to select Motorcycle and UTV models. DR has proven builds for all types of ATV racing motocross, off-road, desert, TT, Cross Country, Flat Track, Drag Racing, Ice Racing, if ATV’s race it DR builds.ĭR also specializes in recreation and stock builds from sand duning to trail riding DR is experience allows them to handle vintage builds to the newest sport models latest models. DR engines have won more races worldwide than any other ATV builder in the world, from Baja to Dakar, Pikes Peak to Loretta Lynn’s DR has built winner’s. This offroad park offers around 10 miles of ATV trails and a simple motocross track (not competition style) on about 200 acres. From full racing engines to stock rebuilds DR does it all. Since that time DR has built thousands of 2 and 4 stroke engines worldwide. Duncan Racing has been building ATV engines since the first ATC 90 hit US soil. |
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